Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells Summary Targeting STAT3 specifically in neutrophils, a type of white blood cell, significantly hinders tumor progression, according to this research. Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02274-9 T cells in space and time Summary A Nature Immunology article published on August 29, 2025, explores the dynamic behavior of T cells within the context of Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02272-x LPS structure shapes Treg cells Summary A 2025 Nature Immunology study reveals that the structure of lipopolysaccharide (LPS), a major component of gram-negative bacteria, significantly influences Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02273-w Humanized mice for MS studies Summary A new study in Nature Immunology (August 29, 2025) highlights the development of humanized mice for studying Multiple Sclerosis (MS). The Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02271-y Antiphage SIR2 in humans Summary A Nature Immunology paper published online on August 29, 2025, reveals a novel antiphage defense mechanism mediated by SIR2 in humans. The Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02256-x IRF3 initiates type I IFN transcription, and this is required for host defense. Here, Chen and colleagues show that RAD18 terminates the transcriptional activity of Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02255-y Alatrakchi and colleagues profile immune cells from liver and blood obtained from patients with MASLD/MASH using single-cell sequencing. They note increased immunoregulatory programs that Read More
Nature Reviews Immunology, Published online: 29 August 2025; doi:10.1038/s41577-025-01220-y A study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins. Summary Read More
Nature Immunology, Published online: 27 August 2025; doi:10.1038/s41590-025-02252-1 TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, Read More
Publisher Correction: Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial Summary A correction was issued regarding the phase 2 SWOG S1512 trial, which investigated anti-PD-1 therapy (pembrolizumab) for unresectable desmoplastic melanoma. The correction Read More
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