Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02249-w Carboxylation switch Summary A groundbreaking study published in Nature Immunology reveals a novel “carboxylation switch” mechanism in immune regulation. Researchers discovered that specific immune cells Read More
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Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02251-2 TLRs are blind to pseudouridine RNA Summary A new study published in Nature Immunology reveals that Toll-like receptors (TLRs), key components of the innate immune Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02248-x Targeting CAFs Summary Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment, influencing cancer progression, metastasis, and immune evasion. This Nature Immunology article Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02250-3 Restoring balanced HSC youth Summary A recent Nature Immunology article highlights promising research aimed at rejuvenating aged hematopoietic stem cells (HSCs). HSCs, responsible for generating Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02201-y TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ Read More
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Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02224-5 Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02221-8 During late gestation, unconventional intraepithelial αβ T cells migrate from the gut to the mammary gland to remodel the tissue for lactation and enhance its mucosal Read More
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Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02218-3 Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the Read More
Nature Reviews Immunology, Published online: 29 July 2025; doi:10.1038/s41577-025-01206-w Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved Read More
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Massively parallel immunopeptidome by DNA sequencing provides insights into cancer
Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation Summary Massively parallel immunopeptidome sequencing (MPIS) uses DNA sequencing to identify peptides presented by MHC molecules on cell surfaces, offering a comprehensive view Read More
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