Nature Immunology, Published online: 21 July 2025; doi:10.1038/s41590-025-02227-2 Tran et al. discuss the role of the gut microbiome and gut microbiome-derived metabolites in T cell biology. Summary Tran et al.’s Nature Immunology Read More
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Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a
Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine Summary This research explores combining oncolytic viruses and p53-enhanced dendritic cell (DC) vaccines to improve cancer immunotherapy. Specifically, DCs Read More
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Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target Summary Ulcerative colitis-associated colorectal cancer (UC-CRC) is a serious complication of ulcerative colitis. This study Read More
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Targeting gut microbiota and arginase boosts MEK inhibitors’ enhancement of
Targeting gut microbiota and arginase boosts MEK inhibitors’ enhancement of antitumour immunity via MHC-I upregulation in colorectal cancer Summary MEK inhibitors, while promising for colorectal cancer (CRC) treatment, often face limited efficacy. This study reveals Read More
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Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T
Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T and CXCL9+ cells after radiotherapy combined with anti-PD-L1 therapy Summary A study using single-cell spatial analysis with the Xenium platform investigated the effects of Read More
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Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy Summary Nanobody-based bispecific antibody engagers offer a promising avenue for cancer immunotherapy. These molecules combine the target specificity of nanobodies, small and stable antibody Read More
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Noncanonical and mortality-defining toxicities of CAR T cell therapy –
Noncanonical and mortality-defining toxicities of CAR T cell therapy Summary CAR T-cell therapy, while revolutionary, can trigger severe toxicities beyond the well-known cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). These less Read More
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Mitochondrial respiration is necessary for CD8<sup>+</sup> T cell proliferation and
Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02202-x Mitochondrial electron transport chain activity provides ATP, generates superoxide, regulates apoptosis and provides the biosynthetic building blocks for growing cells. Here Steinert et al. genetically Read More
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DNA hypomethylation traits define human regulatory T cells in cutaneous
Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02210-x Feuerer and colleagues use multiomic analyses to identify DNA methylation, chromatin accessibility and gene expression programs that govern the tissue adaptation of human skin Treg Read More
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Migrating immune cells globally coordinate protrusive forces – New Study
Nature Immunology, Published online: 15 July 2025; doi:10.1038/s41590-025-02211-w Sixt and colleagues show that, in environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and assemble a Read More
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