Gene regulation in immune cells Archives

A unique p52 NF-κB–ETS1 interaction ushers in a new paradigm

Dr AF Saeed Dr AF Saeed 12th August 2025

Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02246-z A complex of the NF-κB family member p52 and the transcription factor ETS1 is required for B cell germinal center responses to T cell-dependent Read More

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A STUB1–CHIC2 complex inhibits CD8<sup>+</sup> T cells to restrain tumor

Dr AF Saeed Dr AF Saeed 12th August 2025

Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02231-6 LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as Read More

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Six degrees of TGFβ – New Study

Dr AF Saeed Dr AF Saeed 29th July 2025

Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02201-y TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ Read More

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FOXP3 dependence

Dr AF Saeed Dr AF Saeed 2nd July 2025

Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02213-8 FOXP3 dependence Summary A new study published in Nature Immunology reveals a crucial dependency on the transcription factor FOXP3 for the sustained suppressive function of Read More

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Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory

Dr AF Saeed Dr AF Saeed 27th June 2025

Nature Immunology, Published online: 27 June 2025; doi:10.1038/s41590-025-02206-7 Ciofani and colleagues examine the plasticity of Tγδ17 cells in the gut, where they identify a role for the AP-1 transcription factors JUNB and FOSL2 Read More