Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02284-7 CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, Read More
Tags :Gene regulation in immune cells
Education, Research & Positions
Divergent cytokine and transcriptional signatures control functional T follicular helper
Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02258-9 Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and Read More
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More
Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02246-z A complex of the NF-κB family member p52 and the transcription factor ETS1 is required for B cell germinal center responses to T cell-dependent Read More
Education, Research & Positions
A STUB1–CHIC2 complex inhibits CD8<sup>+</sup> T cells to restrain tumor
Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02231-6 LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02201-y TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02213-8 FOXP3 dependence Summary A new study published in Nature Immunology reveals a crucial dependency on the transcription factor FOXP3 for the sustained suppressive function of Read More
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