Epigenetics in immune cells Archives

DNA hypomethylation primes ILC lineage choice – New Study

Dr AF Saeed Dr AF Saeed 18th September 2025

Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02275-8 The effector fates of innate lymphoid cells (ILCs) are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding Read More

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Circadian circuits control plasticity of group 3 innate lymphoid cells

Dr AF Saeed Dr AF Saeed 13th August 2025

Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02240-5 Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt. Read More

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Genetic variation in the activity of a TREM2–p53 signaling axis

Dr AF Saeed Dr AF Saeed 25th July 2025

Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02217-4 Sajti and colleagues identify TREM2 as a critical factor in myeloid cells in response to hyperoxia-induced lung injury in neonates, finding that TREM2 deficiency protects Read More

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Train your histones

Dr AF Saeed Dr AF Saeed 2nd July 2025

Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02214-7 Train your histones Summary A newly published Nature Immunology article highlights the potential for “training” histones, proteins around which DNA is wrapped, to influence immune Read More