GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system Summary GD2 ganglioside, highly expressed in several pediatric central nervous system (CNS) tumors like neuroblastoma and medulloblastoma, presents Read More
Tags :CNS cancer
Education, Research & Positions
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1 Summary Glioblastoma (GBM) is a deadly brain cancer with limited treatment options, and immunotherapy’s effectiveness is often hindered. Read More
Education, Research & Positions
The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH
The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials Summary Two Phase I clinical trials evaluated the safety and efficacy of Ad-TD-nsIL12, Read More
Education, Research & Positions
Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in
Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Summary This phase 1 clinical trial investigated the safety and efficacy of intracerebroventricular (ICV) administration of bivalent CAR T cells Read More
A peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial Summary This phase 1 clinical trial investigates the safety and immunogenicity of a peptide Read More
Education, Research & Positions
Author Correction: Intracerebroventricular bivalent CAR T cells targeting EGFR and
Author Correction: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Summary A Phase 1 clinical trial investigated the safety and feasibility of intracerebroventricular (ICV) administration of bivalent CAR Read More
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