Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More
Tags :Cells
Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More
Thought too hard to do, a new platform evolved proteins in mammalian cells, which could help researchers design drugs that work better in humans. Summary Researchers have developed a new platform for evolving proteins Read More
Education, Research & Positions
The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem
The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS Summary AFM28, a bispecific innate cell engager targeting CD123 and CD16A, demonstrates promising results in eliminating leukemic Read More
Education, Research & Positions
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase 2 trial Summary This Phase 1/Phase 2 trial investigates the safety and efficacy of GD2-targeted CAR T cell therapy in patients with high-risk neuroblastoma, a Read More
Triple-negative breast cancer cells build bridges to activate adipocytes and fuel themselves, highlighting a target for future therapies. Summary Triple-negative breast cancer (TNBC) cells, known for their aggressive nature, create physical connections, or “bridges,” to Read More
Education, Research & Positions
Precision nanobody acts as 'drone strike' against lung cancer cells,
A research team has developed a nanobody-based technology that can precisely identify and attack only lung cancer cells, opening new possibilities for cancer therapy. Summary Researchers have created a targeted lung cancer therapy using nanobodies. Read More
Education, Research & Positions
Expanding the cytokine receptor alphabet reprograms T cells into diverse
Expanding the cytokine receptor alphabet reprograms T cells into diverse states Summary T cells, traditionally defined by a limited set of cytokine receptors, can be drastically reprogrammed by expanding this “receptor alphabet.” Research demonstrates that Read More
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More
Education, Research & Positions
Multimodal profiling reveals tissue-directed signatures of human immune cells altered
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02241-4 Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human Read More
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