Scientists learned about a decade ago that when children were given peanuts in the first few months of life, their chances of developing a peanut allergy… Summary Scientists discovered roughly ten years ago that early Read More
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Education, Research & Positions
Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in
Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Summary This phase 1 clinical trial investigated the safety and efficacy of intracerebroventricular (ICV) administration of bivalent CAR T cells Read More
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Rewiring endogenous genes in CAR T cells for tumour-restricted payload
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery Summary Rewiring CAR T cells to deliver therapeutic payloads directly within the tumor microenvironment offers a promising strategy to enhance efficacy and reduce systemic Read More
Science, Volume 388, Issue 6754, Page 1357-1358, June 2025. Summary Without knowing the specific content of Science, Volume 388, Issue 6754, pages 1357-1358, I can only offer a general summary based on typical journal articles. This issue of Science likely Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02215-6 Y do T cells fail Summary A new study published in Nature Immunology (June 30, 2025) investigates the mechanisms behind T cell exhaustion. The research delves into Read More
Researchers have discovered that SARS-CoV-2, the virus that causes COVID-19, may be changing crucial white blood cells called neutrophils … Summary Scientists have found that SARS-CoV-2 can alter neutrophils, a type of white blood cell vital Read More
Education, Research & Positions
CD4<sup>+</sup> T cells license Kupffer cells to reverse CD8<sup>+</sup> T
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02199-3 Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining Read More
Systemic sclerosis (SSc) or scleroderma is a rare, chronic, autoimmune disorder that hardens connective tissue and muscle in the body. As a result, this ca Summary Systemic sclerosis (SSc), or scleroderma, is a rare autoimmune Read More
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