Abstract IL-33 plays an important role in the early programming of CD8 T cells; however, its contribution to the differentiation of tissue-resident memory T cells in vivo remains poorly defined. After infection of mice with Read More
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Resistance to anti-PD-1 therapy is driven by CD30+ regulatory T cell activity Summary Resistance to anti-PD-1 immunotherapy, a common cancer treatment, is often linked to the suppressive activity of CD30-expressing regulatory T cells (Tregs). Read More
Aging alters the response to CAR T cell therapy Summary Aging significantly impacts the effectiveness of CAR T-cell therapy. Older patients often exhibit poorer responses and increased toxicity compared to younger individuals. This is due Read More
Education, Research & Positions
Nrf2 Regulates Inflammation by Modulating Dendritic Cell–T Cell Crosstalk during
Abstract Every year millions of people are infected with influenza, which can be complicated by secondary bacterial pneumonia. One factor that may contribute to increased susceptibility to secondary bacterial infection is the modulation of inflammatory Read More
Education, Research & Positions
Outcome of second allogeneic hematopoietic cell transplantation in adult patients
Outcome of second allogeneic hematopoietic cell transplantation in adult patients with relapsed B-cell acute lymphoblastic leukemia in the era of new immunotherapeutic agents Summary This study investigates the effectiveness of second allogeneic hematopoietic cell transplantation (Read More
Education, Research & Positions
The MicroRNA miR-223 Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell
Abstract Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression Read More
A new study shows that cells in atherosclerotic blood vessels grow in a way that resembles tumor development. This finding offers new biological insights and could lead to new treatment strategies. Researchers from the University Read More
Nature Immunology, Published online: 27 June 2025; doi:10.1038/s41590-025-02177-9 CD8+ T cell exhaustion and dysfunction are features of a number of diseases associated with chronic antigen exposure and in some cases can be overcome Read More
Nature Immunology, Published online: 27 June 2025; doi:10.1038/s41590-025-02206-7 Ciofani and colleagues examine the plasticity of Tγδ17 cells in the gut, where they identify a role for the AP-1 transcription factors JUNB and FOSL2 Read More
Education, Research & Positions
Tumour-associated vasculature in T cell homing and immunity: opportunities for
Nature Reviews Immunology, Published online: 27 June 2025; doi:10.1038/s41577-025-01187-w The vasculature that forms in tumours and supports tumour growth is abnormal and limits T cell entry into tumours. Here, the authors review how Read More
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