CD8ltsupgtltsupgt Archives

CRISPR screens identify STUB1 as an inhibitor of cytokine signaling

Dr AF Saeed Dr AF Saeed 22nd August 2025

Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More

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SATB1 is a key regulator of quiescence in stem-like CD8+

Dr AF Saeed Dr AF Saeed 22nd August 2025

Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More

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A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor

Dr AF Saeed Dr AF Saeed 12th August 2025

Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02231-6 LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as Read More

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Mitochondrial respiration is necessary for CD8+ T cell proliferation and

Dr AF Saeed Dr AF Saeed 16th July 2025

Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02202-x Mitochondrial electron transport chain activity provides ATP, generates superoxide, regulates apoptosis and provides the biosynthetic building blocks for growing cells. Here Steinert et al. genetically Read More

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IL-4 impairs the formation of skin-resident memory CD8+ T cells

Dr AF Saeed Dr AF Saeed 14th July 2025

Nature Immunology, Published online: 14 July 2025; doi:10.1038/s41590-025-02207-6 Bromley and colleagues show that IL-4 decreases the responsiveness of CD8+ T cells to TGFβ, resulting in impaired formation of CD8+ TRM cells. Summary Bromley Read More

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A liver-centric help circuit revives CD8+ T cells via IL-27

Dr AF Saeed Dr AF Saeed 8th July 2025

Nature Immunology, Published online: 08 July 2025; doi:10.1038/s41590-025-02204-9 Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 Read More

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CD4+ T cells license Kupffer cells to reverse CD8+ T

Dr AF Saeed Dr AF Saeed 1st July 2025

Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02199-3 Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining Read More