Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02276-7 Here the authors show a function for lymph nodes in the maintenance of effector T cell differentiation and function during chronic infection and checkpoint blockade, Read More
Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02224-5 Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02244-1 Adoptive T cell therapies show limited efficacy against solid tumors owing to T cell exhaustion within the tumor microenvironment. A study now reveals that dysregulated Read More
LARP4-mediated hypertranslation drives T cell dysfunction in tumors Summary LARP4, an RNA-binding protein, plays a significant role in tumor-induced T cell dysfunction. Researchers discovered that within tumors, T cells exhibit increased LARP4 expression. This Read More
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