CD8-positive T cells Archives

SATB1 is a key regulator of quiescence in stem-like CD8<sup>+</sup>

Dr AF Saeed Dr AF Saeed 22nd August 2025

Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More

Education, Research & Positions

Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency

Dr AF Saeed Dr AF Saeed 29th July 2025

Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02224-5 Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint Read More

Education, Research & Positions

Aberrant protein translation promotes T cell exhaustion – New Study

Dr AF Saeed Dr AF Saeed 25th July 2025

Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02244-1 Adoptive T cell therapies show limited efficacy against solid tumors owing to T cell exhaustion within the tumor microenvironment. A study now reveals that dysregulated Read More

Education, Research & Positions

LARP4-mediated hypertranslation drives T cell dysfunction in tumors – New

Dr AF Saeed Dr AF Saeed 22nd July 2025

LARP4-mediated hypertranslation drives T cell dysfunction in tumors Summary LARP4, an RNA-binding protein, plays a significant role in tumor-induced T cell dysfunction. Researchers discovered that within tumors, T cells exhibit increased LARP4 expression. This Read More

Education, Research & Positions

Lipids rewire T cell exhaustion

Dr AF Saeed Dr AF Saeed 27th June 2025

Nature Immunology, Published online: 27 June 2025; doi:10.1038/s41590-025-02177-9 CD8+ T cell exhaustion and dysfunction are features of a number of diseases associated with chronic antigen exposure and in some cases can be overcome Read More