IC2Bert: masked gene expression pretraining and supervised fine tuning for robust immune checkpoint blockade (ICB) response prediction Summary IC2Bert proposes a novel deep learning framework for predicting patient response to Immune Checkpoint Blockade (Read More
No strain, no formate gains Summary The phrase “No strain, no formate gains” is a play on the adage “No pain, no gain.” It highlights the relationship between cellular stress (strain) and the production of Read More
Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma Summary Combining MCL-1 inhibition with CD37-directed CAR T-cell therapy shows promise for treating T-cell lymphoma. Read More
The value of acetylation reader YEATS2 in hepatocellular carcinoma management Summary YEATS2, a protein that “reads” acetylated lysine on histones, plays a significant role in hepatocellular carcinoma (HCC) development. Studies indicate it promotes HCC cell Read More
AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression Summary Prostate cancer progression can be fueled by a specific type of macrophage called AR+TREM2+ macrophages. These macrophages, characterized by the androgen receptor (AR) Read More
The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia Summary Chronic lymphocytic leukemia (CLL) cells rely on the unfolded protein response (UPR), a cellular stress response pathway, to survive. The Read More
Autoantibody spark response predicts treatment outcome in patients receiving chemoradiation followed by durvalumab therapy Summary A study revealed that the development of new autoantibodies, termed “autoantibody spark,” following chemoradiation therapy (CRT) predicts the effectiveness of Read More
OH2 oncolytic virus inhibits non-small-cell lung cancer metastasis via β-catenin pathway suppression Summary Oncolytic virus OH2 effectively inhibits non-small-cell lung cancer (NSCLC) metastasis. Researchers demonstrated that OH2 suppresses the Wnt/β-catenin signaling pathway, a key Read More
Nature Reviews Immunology, Published online: 28 July 2025; doi:10.1038/s41577-025-01217-7 Exercise promotes changes in the gut microbiota that enhance anti-tumour T cell responses. Summary A Nature Reviews Immunology article (published July 28, 2025) highlights the connection Read More
A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade Summary This research presents a novel CD27 agonistic antibody engineered for enhanced activity. By promoting hexamerization (Read More
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