Investigating the correlation between IDO1/PD-L1 expression or co-expression and EGFR/KRAS gene mutations in advanced NSCLC Summary This study explores the relationship between IDO1 and PD-L1 expression (both individually and together) and the presence Read More
Defects in antigen processing and presentation: mechanisms, immune evasion and implications for cancer vaccine development Summary Defects in antigen processing and presentation (APP) mechanisms are critical for immune surveillance and cancer control. These defects, arising Read More
Nanotechnology for immuno-oncology Summary Nanotechnology offers promising solutions for immuno-oncology, enhancing cancer immunotherapy’s effectiveness. Nanoparticles can improve drug delivery to tumors and immune cells, overcoming limitations of traditional methods like poor solubility and systemic Read More
Sorafenib-treated Th9 cells exhibit superior anti-tumor effect in lung metastasis Summary Sorafenib, a multi-kinase inhibitor, enhances the anti-tumor activity of Th9 cells (a type of T helper cell) in lung metastasis models. Specifically, sorafenib treatment Read More
The gut microbiota in cancer immunity and immunotherapy Summary The gut microbiota plays a crucial role in shaping both local and systemic immune responses, significantly impacting cancer development and response to immunotherapy. Specific bacterial species Read More
Surprising role of CMV in shaping outcomes of immunotherapy for melanoma — chronic infection yields favourable survival Summary Cytomegalovirus (CMV), a common chronic virus, surprisingly improves immunotherapy outcomes in melanoma patients. Research suggests that individuals with Read More
Real-world study of first-line immunotherapy combined with chemoradiotherapy in esophageal squamous cell carcinoma Summary A real-world study investigated the efficacy of first-line immunotherapy (likely PD-1/PD-L1 inhibitors) combined with chemoradiotherapy (CRT) in patients with esophageal Read More
Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles Summary This research explores a novel approach to combat lung metastasis and recurrence by using CAR (Chimeric Antigen Read More
Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy Summary This research explores a novel approach to improve immunotherapy response in Triple-Negative Breast Cancer (TNBC) using chimeric exosomes. These engineered exosomes, derived from Read More
Pembrolizumab plus axitinib versus sunitinib for advanced clear cell renal cell carcinoma: 5-year survival and biomarker analyses of the phase 3 KEYNOTE-426 trial Summary The KEYNOTE-426 trial investigated pembrolizumab plus axitinib versus sunitinib for advanced clear Read More
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