Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02255-y Alatrakchi and colleagues profile immune cells from liver and blood obtained from patients with MASLD/MASH using single-cell sequencing. They note increased immunoregulatory programs that Read More
Tags :Biomedicine
Nature Reviews Immunology, Published online: 29 August 2025; doi:10.1038/s41577-025-01220-y A study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins. Summary Read More
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TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid
Nature Immunology, Published online: 27 August 2025; doi:10.1038/s41590-025-02252-1 TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, Read More
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Publisher Correction: Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase
Publisher Correction: Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial Summary A correction was issued regarding the phase 2 SWOG S1512 trial, which investigated anti-PD-1 therapy (pembrolizumab) for unresectable desmoplastic melanoma. The correction Read More
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Engineering TCR-preserved allogeneic CAR-T cells: leveraging cancer immune evasion principles
Engineering TCR-preserved allogeneic CAR-T cells: leveraging cancer immune evasion principles to establish T-cell tolerance Summary Engineering allogeneic CAR-T cells that retain their T cell receptor (TCR) could overcome challenges of current CAR-T therapies. By understanding Read More
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Directed evolution-based discovery of ligands for in vivo restimulation of
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells Summary Researchers have developed a directed evolution approach to discover ligands that can specifically restimulate chimeric antigen receptor (CAR) T Read More
Education, Research & Positions
Multiparametric cellular and spatial organization in cancer tissue lesions with
Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline Summary This content focuses on analyzing cancer tissue using a comprehensive, multi-faceted approach. It combines cellular information (characteristics of individual cells) with Read More
Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More
Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More
Targeting the roots of myeloid malignancies with T cell receptors Summary Targeting myeloid malignancies, like leukemia, remains challenging due to disease heterogeneity and relapse risks. A promising approach focuses on using T cell receptors (TCRs) Read More
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