Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for targeting AXL in malignant peripheral nerve sheath tumors associated with NF1 Summary This research investigates the potential of CAR-T cell therapy to treat malignant peripheral nerve Read More
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity Summary Activating both the STING and lymphotoxin-β receptor (LTβR) pathways concurrently enhances B cell-mediated antitumor immunity. Read More
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01225-7 Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus. Summary A Nature Reviews Immunology Read More
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01224-8 B cells that expand following infection with EBV can colonize the brain, where they recruit activated T cells that have potential to cause neuronal Read More
Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia Summary Pre-TCR-targeted immunotherapy aims to eliminate leukemic T cells in T cell acute lymphoblastic leukemia (T-ALL) by targeting the T cell receptor (TCR) before it fully assembles. Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02274-9 T cells in space and time Summary A Nature Immunology article published on August 29, 2025, explores the dynamic behavior of T cells within the context of Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02272-x LPS structure shapes Treg cells Summary A 2025 Nature Immunology study reveals that the structure of lipopolysaccharide (LPS), a major component of gram-negative bacteria, significantly influences Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02273-w Humanized mice for MS studies Summary A new study in Nature Immunology (August 29, 2025) highlights the development of humanized mice for studying Multiple Sclerosis (MS). The Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02271-y Antiphage SIR2 in humans Summary A Nature Immunology paper published online on August 29, 2025, reveals a novel antiphage defense mechanism mediated by SIR2 in humans. The Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02256-x IRF3 initiates type I IFN transcription, and this is required for host defense. Here, Chen and colleagues show that RAD18 terminates the transcriptional activity of Read More
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