A phase Ib/II trial of atezolizumab with cobimetinib or idasanutlin in metastatic estrogen receptor positive breast cancer Summary This phase Ib/II trial investigated the efficacy and safety of atezolizumab (an immunotherapy drug) combined Read More
Tags :Biomedicine
Education, Research & Positions
Granzyme K<sup>+</sup> CD8 T cells slow tauopathy progression by targeting
Nature Immunology, Published online: 24 June 2025; doi:10.1038/s41590-025-02198-4 McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration. Summary Read More
Nature Reviews Immunology, Published online: 16 June 2025; doi:10.1038/s41577-025-01193-y Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate Read More
Education, Research & Positions
Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust
Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses Summary A novel nanoemulsion adjuvant, encapsulating a TLR7/8 agonist, was developed for enhanced and broad-spectrum antiviral immunity. This “Read More
Nature Immunology, Published online: 25 June 2025; doi:10.1038/s41590-025-02209-4 We identify a clonally expanded subset of granzyme K-expressing CD8+ T cells that establish residency in the central nervous system, where they target microglia and Read More
Education, Research & Positions
Innate immune responses to pathogens at the maternal–fetal interface
Nature Reviews Immunology, Published online: 18 June 2025; doi:10.1038/s41577-025-01191-0 During pregnancy, innate immune mechanisms at the maternal–fetal interface are important for protecting the developing fetus from pathogens. However, excessive immune activation can Read More
Education, Research & Positions
Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry
Nature Reviews Immunology, Published online: 24 June 2025; doi:10.1038/s41577-025-01201-1 White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads Read More
Nature Reviews Immunology, Published online: 25 June 2025; doi:10.1038/s41577-025-01202-0 A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T Read More
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