University of Otago – Department of Biochemistry<br />Salary: NZ$97,377 to NZ$148,024 Read more… Credits: jobs.ac.uk DisclaimerRead More
Tags :Biochemistry
Caltech Researchers Upend Decades-Old Model of Mitochondrial Protein Import –
Researchers showed that many mitochondrial proteins enter the organelle during synthesis, guided by folding patterns and structural signals. This discovery revises decades of biochemical models. Mitochondria are organelles most commonly known as the “powerhouses of Read More
Supercharged NK cells: a unique population of NK cells capable of differentiating stem cells and lysis of MHC class I high differentiated tumors Summary A unique population of natural killer (NK) cells, termed “supercharged NK Read More
Put on your thinking cap, and take on this fun challenge. Summary This is a call to action, inviting the reader to engage in a stimulating and enjoyable mental exercise. It encourages the reader to Read More
TIGIT in cancer: from mechanism of action to promising immunotherapeutic
TIGIT in cancer: from mechanism of action to promising immunotherapeutic strategies Summary TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor on T and NK cells that dampens anti-tumor immunity. It competes Read More
Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and
Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma Summary Targeting LINC01711 in cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) shows promise in overcoming immunosuppression in lung Read More
Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy Summary Recent research explores harnessing hypoxia, a common characteristic of “cold” tumors (those resistant to immunotherapy), to enhance breast cancer immunotherapy. By Read More
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1 Summary Glioblastoma (GBM) is a deadly brain cancer with limited treatment options, and immunotherapy’s effectiveness is often hindered. Read More
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation Summary ULBP2 CAR-T cells show promise in improving gastric cancer immunotherapy by targeting and killing tumor cells and simultaneously disrupting the tumor microenvironment. The Read More
MARCO expression on myeloid-derived suppressor cells is essential for their
MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression Summary Myeloid-derived suppressor cells (MDSCs) require MARCO expression to properly differentiate and exert their immunosuppressive functions. MARCO, a scavenger receptor, plays a Read More