Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells Summary Researchers have developed a directed evolution approach to discover ligands that can specifically restimulate chimeric antigen receptor (CAR) T Read More
Defects in antigen processing and presentation: mechanisms, immune evasion and implications for cancer vaccine development Summary Defects in antigen processing and presentation (APP) mechanisms are critical for immune surveillance and cancer control. These defects, arising Read More
A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias Summary A novel CAR-T cell therapy targeting CD84 is showing promise for treating acute myeloid leukemia (Read More
Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function Summary This study investigates the relationship between the functional avidity of anti-B7H3 CAR-T cells and the antigen density required Read More
Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma Summary Combining MCL-1 inhibition with CD37-directed CAR T-cell therapy shows promise for treating T-cell lymphoma. Read More
Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation Summary Massively parallel immunopeptidome sequencing (MPIS) uses DNA sequencing to identify peptides presented by MHC molecules on cell surfaces, offering a comprehensive view Read More
Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification Summary This research presents a novel method for isolating and enriching tumor-reactive T-cells, crucial for effective cancer immunotherapy. It involves Read More
A peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial Summary This phase 1 clinical trial investigates the safety and immunogenicity of a peptide Read More
Structure/Function Studies of Antigen Processing and Presentation The intricate process of antigen processing and presentation is fundamental to the immune response, enabling the recognition of a vast array of pathogens by T cells. This Read More
Antigen Presenting Cells Antigen-presenting cells (APCs) play a crucial role in the immune system, bridging innate and adaptive immunity. They are responsible for capturing, processing, and presenting antigens to T cells, thus enabling the body Read More
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