Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities



Summary

CRISPR base and prime editing offer promising avenues for enhancing T cell immunotherapies by precisely modifying the T cell genome. Unlike traditional CRISPR-Cas9, these techniques avoid double-strand breaks, potentially increasing safety and reducing off-target effects. They enable fine-tuned manipulation of T cell receptor specificity, co-stimulatory signaling, and immune checkpoint regulation.

However, challenges remain, including delivery efficiency to primary T cells, optimizing editing efficiency, and controlling potential off-target effects. Furthermore, understanding the long-term consequences of these edits on T cell function and persistence is crucial. Overcoming these hurdles could unlock a new generation of highly effective and personalized T cell immunotherapies for various diseases.

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