Surprising role of CMV in shaping outcomes of immunotherapy for melanoma — chronic infection yields favourable survival



Summary

Cytomegalovirus (CMV), a common chronic virus, surprisingly improves immunotherapy outcomes in melanoma patients. Research suggests that individuals with a history of CMV infection experience prolonged survival following immunotherapy treatment compared to those without. This beneficial effect is attributed to CMV-induced changes in the immune system, potentially creating a more responsive environment for immunotherapy to target and destroy cancer cells. The findings highlight the complex interplay between chronic infections and cancer treatment, offering new avenues for enhancing immunotherapy efficacy by potentially mimicking or leveraging CMV’s immune-modulating effects.

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