Polyclonal expansion of functional tumor-reactive lymphocytes infiltrating glioblastoma for personalized cell therapy



Summary

This research explores leveraging the body’s own immune system to fight glioblastoma, a deadly brain cancer. The study focuses on expanding existing, naturally occurring tumor-reactive lymphocytes (immune cells) found within the tumor itself. These lymphocytes are polyclonal, meaning they recognize diverse targets on the tumor, potentially overcoming tumor heterogeneity and resistance. By identifying and selectively expanding these functional, tumor-killing lymphocytes in the lab, researchers aim to create a personalized cell therapy where the patient’s own strengthened immune cells are infused back to target and destroy the glioblastoma. This approach offers a promising avenue for more effective and less toxic treatment compared to traditional methods.

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