Nanomechanical binding mechanism of ligands drives agonistic activity



Summary

Ligand binding to receptors triggers biological responses, but the precise mechanism remains unclear. Recent research highlights the crucial role of nanomechanical forces in this process. Ligand binding induces conformational changes in the receptor, generating mechanical forces at the nanoscale. These forces propagate within the receptor, altering its shape and stability, ultimately influencing downstream signaling pathways. Agonistic activity is thus driven by the nanomechanical binding mechanism where force generation and transmission are essential for receptor activation and subsequent biological effects. This suggests targeting these nanomechanical aspects could offer novel therapeutic strategies.

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