Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T and CXCL9+ cells after radiotherapy combined with anti-PD-L1 therapy



Summary

A study using single-cell spatial analysis with the Xenium platform investigated the effects of radiotherapy combined with anti-PD-L1 therapy on tumors. The research revealed that this combination therapy elicits significant anti-tumor responses mediated by specific immune cell populations. Specifically, CXCL13-expressing T cells and CXCL9-expressing cells were identified as key players in the observed therapeutic effects. This spatial analysis provides valuable insights into the complex tumor microenvironment and the mechanisms underlying the success of this combination immunotherapy approach. The findings highlight the importance of these specific immune cell populations in driving anti-tumor immunity following radiotherapy and anti-PD-L1 treatment.

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