ICANS and mortality after CAR-T therapy for NHL patients can be predicted using physical function measures of falls, balance and strength deficits, and use of an assistive device



Summary

Physical function assessments can predict mortality and immune effector cell-associated neurotoxicity syndrome (ICANS) after CAR-T therapy in non-Hodgkin lymphoma (NHL) patients. Specifically, evaluations focusing on falls, balance and strength deficits, and the use of assistive devices correlate with increased risk. This highlights the importance of integrating pre-treatment physical function assessments to identify patients at higher risk of adverse outcomes and to potentially tailor supportive care strategies. Identifying these risk factors early may help improve patient outcomes and optimize the CAR-T therapy process.

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