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How Cysteine Depletion Drives Cells to Burn Fat  – New Study



Absence of cysteine in mice coaxed fat-storing cells to burn energy, causing weight loss and offering potential therapeutic targets to improve metabolic health.



Summary

Deleting cysteine from the diet of mice forced fat-storing cells (adipocytes) to switch from energy storage to energy burning, resulting in significant weight loss. Researchers observed increased mitochondrial activity and fatty acid oxidation within these cells. This suggests that restricting cysteine intake, or targeting specific pathways related to its metabolism, could be a novel therapeutic approach for combatting obesity and related metabolic disorders. The study highlights a previously unrecognized role for cysteine in regulating adipocyte function and metabolic health.

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