Triple-negative breast cancer cells build bridges to activate adipocytes and fuel themselves, highlighting a target for future therapies.



Summary

Triple-negative breast cancer (TNBC) cells, known for their aggressive nature, create physical connections, or “bridges,” to neighboring fat cells (adipocytes). These bridges enable the transfer of lipids from the adipocytes directly into the cancer cells, providing them with crucial fuel for growth and survival. This discovery unveils a novel mechanism by which TNBC cells exploit their microenvironment for energy. Targeting the formation or function of these cellular bridges presents a promising avenue for developing future therapies that could starve TNBC tumors and improve treatment outcomes.

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