Stretching mice skin made it more permeable to microbial metabolites, jump-starting immune defenses and potentially offering a new approach to vaccine delivery.



Summary

Stretching mouse skin enhances its permeability, allowing microbial metabolites to penetrate more easily. This influx triggers an immune response, effectively mimicking an infection. The physical act of stretching itself primes the skin for immune activation. This discovery suggests a novel method for vaccine delivery, where physically manipulating the skin could improve the efficacy of vaccines by facilitating the entry of antigens and boosting the body’s immune response. The technique could be a valuable alternative to traditional injection methods.

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