T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More
Tags :solid
Scientists have discovered that Mars has an interior structure similar to Earth’s. Results from NASA’s InSight mission suggest that the red planet has a solid inner core surrounded by a liquid outer core, Read More
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Mitochondrial Enzyme Sensitizes Solid Tumors to Immunotherapy – New Study
Tumors adapt to their environment to avoid detection. As different cancer treatments progress, tumors mutate and become resistant. Various markers are expr Summary Tumors are adept at evading detection and treatment by adapting to their Read More
Education, Research & Positions
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid
Nature Immunology, Published online: 27 August 2025; doi:10.1038/s41590-025-02252-1 TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, Read More
Education, Research & Positions
Research Fellow – Centre for Experimental Fuel Technologies (CEFT) –
University of Warwick – School of Engineering<br />Salary: £35,116 to £45,413 per annum Read more… Credits: jobs.ac.uk DisclaimerRead More
Challenges and perspectives of CAR-T cell therapy in solid tumours: insights from gastric cancer Summary CAR-T cell therapy, while effective in hematological malignancies, faces significant challenges in solid tumors like gastric cancer. These hurdles include Read More
Education, Research & Positions
Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance
Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance CAR-T cell efficacy in solid tumors Summary Engineering CAR-T cells with the transcription factor FOXP3 can reprogram their metabolism to improve effectiveness against solid tumors. Read More
Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy Summary Human Fas ligand (CD95L) is a key player in immune cell-mediated killing of cancer cells. However, cancer cells can Read More
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