Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02269-6 The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target. Summary The pre-T cell receptor (pre-TCR) is crucial Read More
Tags :immunology
Education, Research & Positions
Type A cholesterol-dependent cytolysins translocate to the <i>trans</i>-Golgi network for
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02277-6 Chen and colleagues show that type A cholesterol-dependent cytolysins, a group of bacteria pore-forming toxins, translocate to the trans-Golgi network to remodel it into a Read More
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Targeting MHC-E as a new strategy for vaccines and immunotherapeutics
Nature Reviews Immunology, Published online: 03 September 2025; doi:10.1038/s41577-025-01218-6 The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective Read More
Supercharged NK cells: a unique population of NK cells capable of differentiating stem cells and lysis of MHC class I high differentiated tumors Summary A unique population of natural killer (NK) cells, termed “supercharged NK Read More
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Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity Summary Activating both the STING and lymphotoxin-β receptor (LTβR) pathways concurrently enhances B cell-mediated antitumor immunity. Read More
Education, Research & Positions
Regulatory KIR<sup>+</sup>CD8<sup>+</sup> T cells in pregnancy – New Study
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01225-7 Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus. Summary A Nature Reviews Immunology Read More
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01224-8 B cells that expand following infection with EBV can colonize the brain, where they recruit activated T cells that have potential to cause neuronal Read More
Education, Research & Positions
Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia – New
Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia Summary Pre-TCR-targeted immunotherapy aims to eliminate leukemic T cells in T cell acute lymphoblastic leukemia (T-ALL) by targeting the T cell receptor (TCR) before it fully assembles. Read More
Education, Research & Positions
TIGIT in cancer: from mechanism of action to promising immunotherapeutic
TIGIT in cancer: from mechanism of action to promising immunotherapeutic strategies Summary TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor on T and NK cells that dampens anti-tumor immunity. It competes Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02274-9 T cells in space and time Summary A Nature Immunology article published on August 29, 2025, explores the dynamic behavior of T cells within the context of Read More
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