Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02280-x Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis. Summary A study published in Read More
Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02276-7 Here the authors show a function for lymph nodes in the maintenance of effector T cell differentiation and function during chronic infection and checkpoint blockade, Read More
Nature Immunology, Published online: 11 September 2025; doi:10.1038/s41590-025-02270-z The thymus is sensitive to acute insults including infection, as well as to injury from chemotherapy and myeloablative conditioning before hematopoietic cell transplantation. Here, Granadier Read More
Nature Reviews Immunology, Published online: 10 September 2025; doi:10.1038/s41577-025-01214-w The actin cytoskeleton is essential for immune cell shape, signalling and function. In this Review, the authors examine how germ-line mutations affecting actin-regulatory proteins, Read More
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More
Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02278-5 Cholesterol-dependent cytolysins produced by diverse bacterial pathogens are internalized by host cells and translocate to the trans-Golgi network (TGN). They remodel the TGN into a Read More
Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02258-9 Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and Read More
Nature Reviews Immunology, Published online: 08 September 2025; doi:10.1038/s41577-025-01219-5 Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. Read More
Nature Immunology, Published online: 08 September 2025; doi:10.1038/s41590-025-02263-y Erlich et al. show that soluble LTα and membrane-bound LTα1β2 lymphotoxins expressed by B cells play distinct roles to attenuate the pathology observed in ileitis. Read More
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02293-6 Publisher Correction: TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells Summary The Nature Immunology paper, originally published online Read More
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