Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice Summary Researchers developed a novel approach combining radiotherapy (RT) with TLR7/8 agonist prodrugs activated by RT within tumors in mice. Read More
Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny Summary Researchers have developed a novel approach to target cancer using modified hematopoietic stem cells (HSCs). They engineer HSCs to express a tumor-specific T cell receptor (Read More
Researchers have discovered that SARS-CoV-2, the virus that causes COVID-19, may be changing crucial white blood cells called neutrophils … Summary Scientists have found that SARS-CoV-2 can alter neutrophils, a type of white blood cell vital Read More
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy Summary Engineering STING-activating nanoadjuvants offers a promising avenue for enhancing cancer immunotherapy by precisely controlling the location and timing of immune stimulation. These Read More
Leukocyte Recruitment Leukocyte recruitment is a critical process in the immune system’s response to infection and injury. It involves the movement of white blood cells (leukocytes) from the bloodstream to sites of inflammation, infection, Read More
Adhesion Molecules in Cellular Migration, Inflammation and Disease Adhesion molecules are integral membrane proteins that play critical roles in cellular interactions and communication. They are essential in facilitating cellular migration, particularly in the context of Read More
Chemokines and Chemoattractants Chemokines and chemoattractants are signaling molecules that play a crucial role in the immune system by directing the movement of cells, particularly immune cells, towards sites of infection, injury, or inflammation. These Read More
Inflammation Inflammation is a complex physiological response to tissue injury, infection, or harmful stimuli. It is an essential component of the body’s innate immune response and plays a crucial role in restoring homeostasis and Read More
Tolerance and Autoimmunity Tolerance and autoimmunity are foundational concepts in immunology that describe how the immune system distinguishes between the body’s own cells and foreign invaders like pathogens. Properly functioning immune tolerance prevents the Read More
Immunopathogenic Mechanisms/Immunogenetics of Autoimmunity Autoimmunity refers to a group of disorders where the immune system mistakenly targets and attacks the body’s own tissues. This aberrant immune response stems from a complex interplay of Read More
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