A peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial Summary This phase 1 clinical trial investigates the safety and immunogenicity of a peptide Read More
Tags :Cancer
Aging alters the response to CAR T cell therapy Summary Aging significantly impacts the effectiveness of CAR T-cell therapy. Older patients often exhibit poorer responses and increased toxicity compared to younger individuals. This is due Read More
Education, Research & Positions
Novel Combination Regimen with Electric Field Therapy Improves Brain Cancer
Glioblastoma is a highly aggressive brain tumor with about a 10% 5-year survival rate. The debilitating disease affects roughly 3 people per 100,000. Accor Summary Glioblastoma is a devastating and aggressive brain cancer with a dismal 5-year survival Read More
Ecological management of the microbiota in patients with cancer Summary Ecological management of the microbiota in cancer patients focuses on manipulating the gut microbiome to improve treatment outcomes and overall health. Cancer therapies like chemotherapy Read More
Education, Research & Positions
HAPIR: a refined Hallmark gene set-based machine learning approach for
HAPIR: a refined Hallmark gene set-based machine learning approach for predicting immunotherapy response in cancer patients Summary HAPIR is a machine learning method designed to predict a cancer patient’s response to immunotherapy. It leverages Read More
Education, Research & Positions
Adding durvalumab to perioperative FLOT improves gastric cancer outcomes
Adding durvalumab to perioperative FLOT improves gastric cancer outcomes Summary Adding the immunotherapy drug durvalumab to the standard perioperative chemotherapy regimen FLOT significantly improves outcomes for patients with resectable gastric or gastroesophageal junction cancer. The Read More
Education, Research & Positions
Correction: Multicenter phase Ib/II study of second-line durvalumab and tremelimumab
Correction: Multicenter phase Ib/II study of second-line durvalumab and tremelimumab in combination with paclitaxel in patients with biomarker-selected metastatic gastric cancer Summary A multicenter phase Ib/II clinical trial investigated the efficacy and safety Read More
Education, Research & Positions
Tumour-associated vasculature in T cell homing and immunity: opportunities for
Nature Reviews Immunology, Published online: 27 June 2025; doi:10.1038/s41577-025-01187-w The vasculature that forms in tumours and supports tumour growth is abnormal and limits T cell entry into tumours. Here, the authors review how Read More
Education, Research & Positions
Mobilizing antigen-presenting mast cells in anti-PD-1-refractory triple-negative breast cancer: a
Mobilizing antigen-presenting mast cells in anti-PD-1-refractory triple-negative breast cancer: a phase 2 trial Summary This phase 2 trial explores a novel approach to overcome resistance to anti-PD-1 immunotherapy in triple-negative breast cancer (TNBC). Researchers aim to Read More
A phase Ib/II trial of atezolizumab with cobimetinib or idasanutlin in metastatic estrogen receptor positive breast cancer Summary This phase Ib/II trial investigated the efficacy and safety of atezolizumab (an immunotherapy drug) combined Read More
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