Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment



Summary

Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich environment to restore anti-tumor immunity. Researchers found that lactic acid upregulates MondoA, which in turn inhibits TXNIP, leading to reduced T-cell activation and suppressed immune responses. Importantly, targeting MondoA or supplementing TXNIP reversed this immunosuppression, enabling T-cells to effectively target and kill tumor cells. These findings suggest that modulating the MondoA-TXNIP pathway could be a promising strategy to enhance anti-tumor immunity and improve cancer immunotherapy outcomes in tumors with high lactic acid production.

Read more…

Credits: Source

This post is part of “Science/Immunology News”, Follow for more…!!!