Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02271-y

Antiphage SIR2 in humans



Summary

A Nature Immunology paper published online on August 29, 2025, reveals a novel antiphage defense mechanism mediated by SIR2 in humans. The research, identified by the DOI: 10.1038/s41590-025-02271-y, suggests a role for SIR2, a protein previously known for its involvement in chromatin silencing and aging, in protecting human cells against bacteriophage infections. The study potentially uncovers a new layer of the human immune system and highlights the complex interplay between human cells and bacteriophages. This discovery opens avenues for exploring novel therapeutic strategies against phage-related pathologies.

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