Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis – New Study
Nature Immunology, Published online: 08 September 2025; doi:10.1038/s41590-025-02263-y
Erlich et al. show that soluble LTα and membrane-bound LTα1β2 lymphotoxins expressed by B cells play distinct roles to attenuate the pathology observed in ileitis.
Summary
Erlich et al. in Nature Immunology (September 2025) reveal that B cell-derived lymphotoxins, specifically soluble LTα and membrane-bound LTα1β2, have unique roles in mitigating ileitis pathology. Their research demonstrates a previously unappreciated complexity in how these two forms of lymphotoxin contribute to immune regulation within the gut. The study highlights that B cell-produced lymphotoxins are not simply redundant molecules, but rather distinct effectors that work to dampen inflammatory responses in the context of ileitis.
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