Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02258-9

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrogate TFH heterogeneity in mice and humans.



Summary

Dalit, Tan, and colleagues’ research, published in Nature Immunology, offers a comprehensive multiomic analysis of T follicular helper (TFH) cell responses to various pathogens. This study unveils a framework for transcriptional plasticity within TFH cells, providing crucial insights into how these cells adapt to different threats. Furthermore, the research introduces novel tools designed to investigate the complex heterogeneity of TFH cells, both in mice and humans. This work promises to advance our understanding of TFH cell biology and its role in immune responses.

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