Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02248-x

Targeting CAFs



Summary

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment, influencing cancer progression, metastasis, and immune evasion. This Nature Immunology article explores novel strategies for targeting CAFs to enhance anti-tumor immunity and improve cancer therapy outcomes. It likely investigates various mechanisms of CAF modulation, potentially focusing on disrupting CAF signaling pathways, depleting CAFs directly, or reprogramming them to a less tumor-promoting phenotype. By modulating CAFs, researchers aim to weaken the tumor’s defenses, making it more susceptible to immune cell attack and conventional cancer treatments. Ultimately, the article advocates for developing CAF-targeted therapies as a promising avenue for cancer treatment.

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