Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02242-3

When dendritic cells migrate through narrow gaps, they transiently assemble a mechanosensitive actin structure in front of their nucleus. This structure pushes outward against the surrounding tissue to help widen a path so the bulky cell body can pass through. At the same time, it acts as a mechanical ‘capacitor’ that helps the cell to balance forward protrusion at the leading edge and outward protrusion at the cell body.



Summary

Dendritic cells, critical for immune response, face physical challenges navigating tight spaces. This study reveals they form a transient, actin-based structure ahead of their nucleus during migration. This structure acts as a mechanical wedge, widening pathways for the cell body’s passage through dense tissue. Simultaneously, it functions as a “mechanical capacitor,” coordinating forward movement at the cell’s front with outward expansion at the cell body. This balancing act ensures efficient migration despite physical constraints, highlighting the interplay between cellular mechanics and immune function.

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