LARP4-mediated hypertranslation drives T cell dysfunction in tumors



Summary

LARP4, an RNA-binding protein, plays a significant role in tumor-induced T cell dysfunction. Researchers discovered that within tumors, T cells exhibit increased LARP4 expression. This elevated LARP4 leads to hypertranslation, meaning increased protein production, of specific mRNAs. Specifically, it enhances the translation of mRNAs encoding proteins involved in T cell exhaustion and suppression, such as PD-1. This hypertranslation ultimately contributes to the impaired ability of T cells to effectively combat cancer cells within the tumor microenvironment, highlighting LARP4 as a potential therapeutic target to restore T cell function.

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