Nature Immunology, Published online: 21 July 2025; doi:10.1038/s41590-025-02227-2

Tran et al. discuss the role of the gut microbiome and gut microbiome-derived metabolites in T cell biology.



Summary

Tran et al.’s Nature Immunology article explores the intricate link between the gut microbiome, microbiome-derived metabolites, and T cell biology. The research likely delves into how specific microbial communities and their metabolic products influence T cell development, differentiation, and function within the gut and systemically. The study aims to understand how these interactions impact immune responses, potentially offering insights into autoimmune diseases, inflammatory conditions, and infectious disease susceptibility. This work highlights the microbiome’s crucial role in shaping T cell immunity, paving the way for microbiome-targeted therapies.

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