T cells require mitochondria to proliferate, function and generate memory – New Study
Nature Immunology, Published online: 22 July 2025; doi:10.1038/s41590-025-02226-3
Using genetic modifications to dissect mitochondrial functions, we found that, on acute stimulation, CD8+ T cells require mitochondrial metabolism to sustain proliferation and prevent exhaustion. Mitochondria-derived reactive oxygen species are also needed to generate memory CD8+ T cells.
Summary
A Nature Immunology study published in July 2025 reveals the critical role of mitochondrial function in CD8+ T cell immunity. Through genetic modification experiments, researchers demonstrated that during acute stimulation, CD8+ T cells rely on mitochondrial metabolism for sustained proliferation and exhaustion prevention. Furthermore, mitochondria-derived reactive oxygen species (ROS) are essential for the formation of memory CD8+ T cells. These findings highlight the importance of targeting mitochondrial pathways to enhance CD8+ T cell responses in immunotherapy.
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