Nature Immunology, Published online: 23 July 2025; doi:10.1038/s41590-025-02223-6

The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents T cell dysfunction, and that dietary methionine can improve the efficacy of cancer immunotherapy in mice.



Summary

A recent Nature Immunology study reveals the importance of methionine in T cell activation within the nutrient-poor tumor microenvironment. Researchers discovered that early methionine availability is crucial for optimal T cell function, preventing T cell dysfunction and exhaustion. Furthermore, they demonstrated that supplementing dietary methionine improved the effectiveness of cancer immunotherapy in mouse models. This suggests that manipulating dietary methionine levels could enhance anti-tumor immune responses and improve cancer treatment outcomes.

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