Nature Immunology, Published online: 15 July 2025; doi:10.1038/s41590-025-02211-w

Sixt and colleagues show that, in environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and assemble a central F-actin pool that pushes outward to transiently dilate a path for the nucleus.



Summary

Sixt et al. report a novel mechanism leukocytes use to navigate constricted environments. When faced with pores too small for free passage, these cells position their nucleus behind the centrosome. They then assemble a concentrated pool of F-actin, which actively pushes outwards. This force transiently expands the pore, creating a path that allows the nucleus to squeeze through. This discovery highlights a dynamic and spatially organized cellular process enabling immune cell migration in challenging microenvironments.

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