Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages – New Study
Nature Immunology, Published online: 23 July 2025; doi:10.1038/s41590-025-02208-5
Here Zhu et al. investigate the ontogeny of type 2 dendritic cells (DC2s) in mice. Using Klf4 expression to distinguish conventional DC precursors from plasmacytoid DCs, they identify two pre-DC2 populations with their development controlled by TCF4 and KLF4 that give rise to DC2A and DC2B cells.
Summary
Zhu et al. published in Nature Immunology, July 2025, explored the developmental origins of type 2 dendritic cells (DC2s) in mice. By leveraging Klf4 expression to differentiate between conventional DC precursors and plasmacytoid DCs, the research team discovered two distinct pre-DC2 populations. Their findings demonstrate that the development of these precursor populations, ultimately giving rise to DC2A and DC2B cells, is regulated by the transcription factors TCF4 and KLF4. This study sheds light on the complex developmental pathway of DC2s and the critical role of specific transcription factors in their differentiation.
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