Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02201-y

TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ T cell tissue residence in skin.



Summary

A Nature Immunology study published July 29, 2025, reveals that TGFβ signaling is crucial for CD8+ T cells to become tissue-resident. The research highlights the role of TGFβ in establishing this residency within the skin. Specifically, the study demonstrates that both IL-4 and PD-1 are interconnected with TGFβ signaling pathways. This connection ultimately regulates the process of CD8+ T cells differentiating and establishing themselves as long-term residents within the skin tissue. The findings shed light on key mechanisms controlling immune cell positioning and persistence in tissues.

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