Nature Reviews Immunology, Published online: 22 July 2025; doi:10.1038/s41577-025-01200-2

Endometritis can cause infertility and recurrent pregnancy loss and is an important medical and veterinary issue. Here, Nash and Giles provide an overview of the various models that can be used to study uterine inflammation and discuss their value for developing new therapies.



Summary

Nash and Giles, in a Nature Reviews Immunology article, address endometritis, a significant cause of infertility and recurrent pregnancy loss in both humans and animals. The review focuses on different models used to study uterine inflammation, highlighting their importance in developing effective treatments for this condition. The authors emphasize the utility of these models for understanding the underlying mechanisms of endometritis and for testing potential new therapies, ultimately aiming to improve reproductive health outcomes.

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