Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer



Summary

Pancreatic cancer often resists immunotherapy, and this resistance is linked to elevated levels of spermine, a polyamine involved in cell growth and survival. Researchers found that high spermine levels, produced by the enzyme spermine synthase (SMS), suppressed T cell activity within the tumor microenvironment. Inhibiting SMS with a drug called AMD prevented spermine production, reinvigorated T cell function, and improved the effectiveness of immunotherapy in preclinical models of pancreatic cancer. This suggests that targeting spermine metabolism, specifically SMS, could be a promising strategy to overcome immunotherapy resistance and improve treatment outcomes for patients with pancreatic cancer.

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