Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy



Summary

Recent research explores harnessing hypoxia, a common characteristic of “cold” tumors (those resistant to immunotherapy), to enhance breast cancer immunotherapy. By strategically manipulating the tumor microenvironment to induce controlled hypoxia, researchers aim to convert these cold tumors into “hot” tumors, characterized by increased immune cell infiltration and activity. This approach involves triggering specific cellular responses under hypoxic conditions that ultimately promote the recruitment of immune cells, making the tumor more susceptible to checkpoint inhibitors and other immunotherapy strategies. Ultimately, this could unlock new avenues for treating breast cancer patients who currently do not respond to immunotherapy.

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