Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella



Summary

Researchers explored a novel cancer therapy using tumor-targeting Salmonella bacteria. They engineered the bacteria to express a fusion protein combining interleukin-2 (IL-2), an immune-boosting cytokine, with flagellin, a potent immune stimulator. This targeted delivery of IL-2 and flagellin to the tumor site aimed to directly kill cancer cells and enhance the anti-tumor immune response. The study investigated the efficacy of this engineered Salmonella in pre-clinical models, potentially paving the way for a new approach to cancer immunotherapy by combining targeted bacterial delivery with potent immune stimulation.

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