Pressure from surrounding tissues activates invasive programs in cancer cells. This mechanical stress rewires epigenetic regulation. Cancer cells are notoriously adaptable, capable of shifting their characteristics as they spread throughout the body. Many of these shifts stem from epigenetic changes, which influence how DNA is organized and expressed rather than altering the genetic code itself. […]



Summary

Mechanical stress from surrounding tissues can trigger invasive behavior in cancer cells by altering their epigenetic regulation. This stress essentially reprograms how DNA is organized and expressed, leading to changes in the cells’ characteristics as they spread. This highlights cancer cells’ adaptability, driven by epigenetic modifications rather than genetic mutations. Understanding this mechanism could unlock new therapeutic strategies targeting the epigenetic responses to mechanical cues, potentially inhibiting cancer metastasis.

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